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This article is intended for qualified aesthetic practitioners. It is not patient advice and does not replace the manufacturer's instructions for use or your own training.
NCTF 135 HA is Fillmed's polyrevitalising solution: non-crosslinked hyaluronic acid combined with vitamins, amino acids, minerals, coenzymes and nucleic acids, delivered into the superficial skin over a short course of sessions. It is used to work on skin quality, meaning hydration, radiance and fine lines, and it does not add volume. If you are deciding whether it belongs on your treatment menu, the questions that matter are what is in the vial, how good the evidence is, which protocol to follow and how to deliver it. This guide takes those in turn.
The product was developed by Filorga Laboratories in France and is now sold under the Fillmed name. Fillmed's UK product page dates the formula to 1978 and describes it as CE licensed for injection. It sits in the mesotherapy family, and you will also see it called an NCTF skin booster or a polyrevitaliser.
The hyaluronic acid is non-crosslinked sodium hyaluronate of non-animal origin. That single fact sets patient expectations. A free HA solution spreads through the tissue and is not designed to hold a shape, so NCTF 135 HA will not project a cheek, define a lip border or fill a deep fold. Patients who want structural change need a crosslinked filler. Patients whose complaint is dull, dry or finely lined skin are the ones this product was made for.
Fillmed currently lists 60 active ingredients, grouped as 12 vitamins, 24 amino acids, 6 minerals, 6 coenzymes and 5 nucleic acids, alongside other components such as glutathione. Older literature gives a different total. A 2015 review in Clinical, Cosmetic and Investigational Dermatology describes 53 components plus high molecular weight hyaluronic acid, and you will find other totals in distributor listings.
For your own patient literature, quote the manufacturer's current figure and avoid copying numbers from third-party sites. The same review notes that the solution is sterilised by double filtration and not by autoclaving, in order to preserve the vitamins and the hyaluronic acid.
The long ingredient list has a practical consequence at consultation. A patient with a known sensitivity to any listed component, including individual B vitamins, needs that picked up in the medical history before you draw up.
NCTF 135 HA has peer-reviewed data behind it, though the evidence base is modest and much of it has manufacturer involvement. The 2015 review above, for example, acknowledges medical writing support funded by Filorga.
The most relevant controlled study is a randomised, controlled, multicentre trial published in the Journal of Dermatological Treatment in 2023. It enrolled 146 participants and compared three NCTF 135 HA injection sessions plus a moisturising cream against the cream alone. At day 75 and day 120 the treated group showed significantly reduced wrinkle scores in each of the assessed areas and better facial radiance scores. Skin hydration had increased when measured seven days after the final session. Adverse events were mostly mild, related to the injections and resolved within 48 hours.
A 2026 multicentre non-inferiority trial in 188 participants used NCTF 135 HA as one of two hyaluronic acid solutions for neck wrinkles, given in three sessions four weeks apart. No serious adverse events were reported in either group.
Be measured when you relay these findings. The trials report improvements in graded scores at set time points. They do not promise a result for an individual patient, and your marketing should not either.
The protocol Fillmed publishes through IMCAS is three initial sessions 15 days apart, followed by two maintenance sessions one month apart. That gives five sessions over roughly three months.
Real-world practice clusters around the same starting point. An international survey of aesthetic physicians published in the Journal of Cosmetic Dermatology in 2025 found that most respondents give NCTF 135 HA over multiple sessions, with three the most common number (39.7%). The 2023 trial also used three sessions.
For clinic planning, that means:
Fillmed lists three routes of delivery for NCTF 135 HA: mesotherapy injection at superficial and deeper levels, application with microneedling, and delivery through its Nanosoft microneedle device, which works at a depth of 0.6mm. The IMCAS product profile describes the injection as intradermal or subdermal.
Most practitioners who inject by hand use one or a mix of three approaches:
Whichever you use, depth control is the skill that separates a comfortable treatment from a bruised one. The product is intended for superficial placement and there is no benefit in going deeper than you were trained to.
Fillmed's professional pack comes with 18G draw-up needles, 3ml syringes and two types of injection needle: 30G 12mm and 32G 4mm. The short 32G needle limits depth mechanically, which makes it the natural pick for micropapules. The longer 30G gives you the angle and reach for nappage. If you buy vials without the kit, or get through needles faster than the box supplies them, keep both sizes in your needle stock and change needles often. Fine-gauge tips blunt quickly over multiple punctures and a blunt tip means more discomfort and more bruising.
The areas Fillmed names are the face including the periorbital region, the neck, the décolletage, the backs of the hands and the inner arms. "NCTF under eye" attracts a lot of patient searches, so expect to be asked about it. Periorbital skin is thin and highly vascular, bruising shows readily, and swelling can linger. Treat it as an advanced area and only inject there if your training covered it specifically.
The manufacturer lists applying the solution before microneedling as an alternative to injection, which can suit needle-averse patients. Use a sterile, single-use cartridge and check that your insurer covers the combination.
Good candidates are patients with early to moderate signs of skin ageing whose main complaints are texture, dehydration, dullness and fine lines. Poor candidates are those expecting lift, contour or volume replacement, and anyone who cannot commit to a course.
The instructions for use are the authority on contraindications and you should read the current version supplied in the box. In general terms, exclusions for injectable skin treatments include pregnancy and breastfeeding, active infection or inflammation at the treatment site, and known hypersensitivity to any ingredient. Take a full medication history, including anticoagulants and supplements that increase bruising.
Consent should cover the expected short-term effects seen in the trials, namely injection-site redness, swelling, papules and bruising, as well as the course-based nature of the treatment. Record the batch number and expiry date in the patient's notes at every session.
The 2025 survey found practitioners split evenly between using NCTF 135 HA alone and using it within a combination plan. The procedures most often paired with it were hyaluronic acid fillers, botulinum toxin, microneedling and peels.
Sequencing and spacing between treatments should follow the instructions for each product and the protocols you were taught. With a new patient, introduce one treatment at a time so that any reaction can be attributed.
Buy from a supplier that can show a traceable route back to the manufacturer. On delivery, check that the outer packaging is sealed, that the CE marking and batch number are present and that the expiry date leaves you enough time to complete planned courses. Store the vials as the instructions for use direct.
Filler World stocks Fillmed NCTF 135 HA in the 5 x 3ml pack, along with the rest of the Fillmed range. If you are weighing it against other injectable skin quality products, our skin booster collection lists the alternatives side by side.
It is used to improve skin quality. Published trial data report reduced fine wrinkle scores, better radiance scores and increased hydration after a three-session course. It is not a volumising product and will not replace a dermal filler where structure is needed.
They are different types of product, so the question is which suits the patient. NCTF 135 HA is a multi-ingredient mesotherapy solution placed at many superficial points across the treatment area. Profhilo is a high-concentration hyaluronic acid bioremodeller placed at a small number of defined points. Choose on the basis of indication, skin condition and how many appointments the patient will accept. Our guide to Profhilo injection points covers that technique in detail.
There is no fixed duration to quote. The 2023 randomised trial recorded improvements at its day 75 and day 120 assessments. Fillmed's protocol builds in two monthly maintenance sessions after the initial three, and many practitioners review patients after the course to plan further maintenance.
Hydration was measurably higher seven days after the last injection in the 2023 trial, and wrinkle and radiance scores had improved by day 75. Tell patients to judge the outcome after the full course and not after the first session.
NCTF 135 HA is a long-established mesotherapy product with peer-reviewed data to draw on. It works on skin quality over a course of sessions and is delivered superficially by needle or microneedling. Select patients whose concerns match what it does, follow the manufacturer's protocol, document every session and keep your claims in line with the published data.
