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This article is intended for qualified aesthetic practitioners and prescribers. It is not consumer advice.
Rejuran is a polynucleotide (PN) injectable range developed by the Korean company PharmaResearch, and it is one of the most searched-for skin booster names in the UK. For practitioners, the useful questions are practical ones: what separates Rejuran Healer, Rejuran I and Rejuran S, where each sits in a treatment plan, how it is placed, and who should not be treated. This guide covers those points, along with sourcing and storage considerations for clinics buying the range.
Rejuran products are built on polynucleotides: long-chain DNA fragments purified from salmon. The PN chains are not a volumiser in the way a cross-linked hyaluronic acid filler is. They are used as a bioregenerative skin quality treatment, injected superficially to support the dermal environment rather than to lift or project tissue.
That distinction matters for consultation. Patients often arrive having seen Rejuran described online as "salmon DNA filler". Managing expectations early (texture, hydration and skin quality over a course, not immediate structural change) avoids disappointment and keeps your consent conversation honest.
It is also worth separating the injectable range from the Rejuran-branded cosmeceuticals (ampoules, serums, creams and masks) that dominate consumer search results and marketplaces. Those topical products are a different category entirely. When patients mention "using Rejuran at home", clarify what they mean before you plan treatment.
You will see PN and PDRN (polydeoxyribonucleotide) used interchangeably online, but they are not the same. EyeWiki's clinical summary describes PN as having longer nucleotide chains, a higher molecular weight and a distinct scaffold structure compared with PDRN (EyeWiki: Periorbital Polynucleotide Injections). For a deeper look at how the two compare at a molecular level, see the open-access review Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives. The Rejuran injectables discussed here are PN products.
The three injectables most UK practitioners work with differ mainly in rheology and intended area. Always confirm current indications, depth and volume against the instructions for use (IFU) supplied with the batch you receive, since packaging and wording can vary by market.
Rejuran Healer is the original, general-purpose product in the range, supplied as 2 x 2ml syringes. It is the full-face workhorse: cheeks, forehead, perioral skin and the neck are typical areas. Practitioners usually reach for it when the complaint is overall skin quality, such as dullness, fine crepiness, early laxity or a rough texture, rather than a single focal problem.
Rejuran I is formulated for the periorbital area, where the skin is thin and unforgiving. Its more liquid texture is designed to spread evenly with a lower risk of visible lumping, which is the main concern under the eye. It suits patients with crepey, thin infraorbital skin and fine lines, and it can be a sensible option where a tear trough filler is not indicated or not wanted. It does not replace volume where there is a true structural hollow.
Rejuran S is the scar-focused product; the "S" stands for scar. It has a more viscous gel structure than Healer or I, so it is placed into and beneath atrophic scars and depressed areas, often in a targeted pattern rather than across the whole face. Practitioners commonly combine it with a dedicated scar protocol, including subcision or energy-based treatments where appropriate and within your competence.
You can see the full current line-up, including stock levels, in the Rejuran collection.
A simple way to frame product selection is to start with the main complaint, then the area:
Many plans use more than one product in the same course. For example, a patient with acne scarring on the cheeks and general dullness elsewhere might receive Rejuran S into the scarred zones and Healer across the remaining face. Write the rationale into your treatment record so the plan is clear at follow-up.
Polynucleotides are placed in the dermis, not deep onto bone or into fat pads. EyeWiki's summary describes dermal delivery using a 33G needle, or a 25G or 30G cannula, with small aliquots in the region of 0.01ml to 0.1ml per point, and notes that topical anaesthetic is commonly applied after the skin is cleansed (EyeWiki).
Common techniques include:
In the periorbital area, keep aliquots small, stay superficial and avoid cross-hatching over a limited surface. Visible papules are expected immediately after a microbolus technique and should be explained to the patient before you start, so they are not surprised in the mirror.
Fine, sharp needles with a short bevel give you control over superficial dermal placement. If you prefer a cannula for the infraorbital region or for patients prone to bruising, choose a gauge and length that suits the area. Fresh, appropriately sized consumables for each patient are a basic infection-control requirement, and it is worth keeping a range of gauges in stock so you are not improvising on the day.
Polynucleotides are generally given as a course rather than a single session. EyeWiki reports that a course of two to three treatments spaced around two weeks apart is commonly recommended, with top-up treatment typically considered after six to twelve months (EyeWiki). Some clinics use slightly longer intervals for Healer on the full face; follow the IFU and your own clinical judgement.
Book a review appointment and take standardised clinical photographs at baseline and each visit for your records. Response varies between individuals, and documenting it properly protects both you and the patient. Avoid promising specific outcomes or timescales in marketing or consultation.
Because PN is derived from salmon, ask specifically about fish and seafood allergy during your medical history. EyeWiki advises that polynucleotides should not be offered to patients with fish or shellfish allergies, because a small risk of hypersensitivity remains despite purification (EyeWiki). Other points to screen for include:
Expected side effects are mostly local: redness, swelling, small papules and occasional bruising, which usually settle within hours to a few days. Give written aftercare covering sun protection, avoiding make-up on the day, and avoiding strenuous exercise, saunas and alcohol for the first 24 hours or so. Make sure the patient knows how to contact the clinic out of hours if they notice anything unexpected.
Rejuran is widely counterfeited and grey-imported, particularly through online marketplaces. Buy only from a supplier that can trace the product, provide batch and lot information, and supply it with the correct IFU and labelling. Check that packaging, lot numbers and expiry dates are intact and consistent on arrival, and record the batch number of every syringe you use in the patient's notes so you can trace it if a reaction or recall occurs.
Store the product according to the manufacturer's instructions on the carton, away from direct heat and sunlight, and do not use a syringe that has been opened, damaged or is past its expiry date. Rejuran sits within the wider skin booster range, so it is easy to plan orders alongside your other bioremodelling and hydration products.
Yes. Rejuran Healer, Rejuran I and Rejuran S are supplied to qualified practitioners in the UK through specialist aesthetic wholesalers. Buy from a traceable supplier and check the batch, labelling and IFU on every delivery.
Healer is the general skin quality product for broader areas such as the cheeks and neck. Rejuran S has a more viscous gel structure and is used for atrophic scars and depressed areas. Many treatment plans combine the two.
Rejuran I is formulated for the periorbital area. Its more liquid texture spreads evenly in thin skin and lowers the risk of visible lumping. It improves skin quality rather than replacing lost volume, so assess whether a structural tear trough deficit needs a different approach.
They work differently, so one is not simply better than the other. Microneedling creates controlled micro-injury across the surface, while Rejuran places polynucleotides directly into the dermis. Some practitioners combine or alternate them within a skin quality plan, depending on the patient's skin and goals.
Patients with fish or seafood allergy should not be treated with salmon-derived polynucleotides. Defer treatment in pregnancy, breastfeeding and active skin infection, and take extra care with bleeding disorders, anticoagulants and autoimmune conditions.
Rejuran is a skin quality tool, not a volumiser. Healer covers general rejuvenation, I is designed for thin periorbital skin, and S targets scarring. Select the product by complaint and area, place it superficially in small aliquots, plan a course with documented reviews, and screen carefully for fish allergy. Buying from a traceable UK supplier and recording batch numbers keeps your practice safe and auditable.
