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The polynucleotide brands most UK clinics choose between are Plinest, Nucleofill, Rejuran, Vitaran, Croma's PolyPhil (formerly PhilArt) and Ameela, with newer lines such as LUMI-PN arriving behind them. They are not interchangeable. Concentration, total dose per syringe, viscosity, added hyaluronic acid and the amount of published evidence all differ, and those differences decide which product suits which area. This guide compares the main brands on the points that affect treatment planning and purchasing.
This article is intended for qualified aesthetic practitioners. It is not patient advice and does not replace the manufacturer's instructions for use.
Polynucleotide injectables are gels containing purified chains of nucleotides derived from fish DNA, usually salmon or trout, placed intradermally. The Journal of Aesthetic Nursing's introduction to the category describes them as long, highly purified nucleotide chains in a gel carrier that contains no hyaluronic acid, aimed at the dermal fibroblast. That is the common ground. Beyond it, five variables separate one product from another: concentration in mg/ml, total polynucleotide per syringe, viscosity, co-ingredients, and the treatment area on the label.
Brands are usually marketed on percentage strength, yet syringe volumes vary enough to change the picture. Plinest contains 20 mg/ml in a 2 ml syringe, which is 40 mg of polynucleotide. Nucleofill Strong is the more concentrated gel at 25 mg/ml (2.5%), but in a 1.5 ml syringe it delivers 37.5 mg. LUMI-PN Face matches Plinest at 20 mg/ml and comes in a 2.5 ml syringe, giving 50 mg. If you are costing a full face, neck and décolletage session, work from milligrams and millilitres per syringe, not the headline percentage.
The concentrations quoted in this article come from the manufacturers' labelling as shown on the individual product listings in our range. Formulations and pack sizes change, so confirm each figure against the instructions for use in the box.
These terms are used loosely in supplier catalogues. PN-HPT is Mastelli's trademark for its purification process and applies only to that manufacturer's products. PDRN and PN are often used interchangeably on packaging from other makers. Since the naming is inconsistent, the labelled concentration, the stated source and the regulatory marking tell you more than the acronym does.
Made in Italy by Mastelli, this is one of the longest-established ranges. Plinest is 20 mg/ml PN-HPT in a 2 ml syringe supplied with two 30G ½ inch needles, and the manufacturer suggests it for prevention and for maintaining skin quality in younger patients. Plinest Eye drops to 7.5 mg/ml for the periocular area. Newest is a hybrid: 10 mg/ml PN-HPT with 10 mg/ml non-cross-linked hyaluronic acid and mannitol, positioned for mature, dehydrated skin. Plinest Hair covers scalp protocols. The range's main advantage is its research base: PN-HPT has been the subject of a published consensus report and several clinical papers, including the periorbital study discussed below.
The Nucleofill range is graded by strength, which makes selection simple. Strong is 2.5% in 1.5 ml and is listed as a Class III CE-marked medical device for mature or photo-aged skin, with atrophic scars and stretch marks among its labelled uses. Medium is 2%. Soft Plus is the periocular product, described by the manufacturer as having the lowest molecular weight in the range to limit post-treatment oedema, and Medium Plus is positioned for the scalp.
The Korean Rejuran range uses salmon-derived polynucleotide and differentiates mainly by rheology. The original Rejuran is the general facial product. Rejuran I has a more liquid texture for the thin skin around the eyes, which the manufacturer says lowers the risk of lumping. Rejuran S is deliberately viscous and aimed at depressed acne scars.
Vitaran is another salmon-derived line. Vitaran I is labelled at 20 mg/ml (2%) in a 1 ml syringe and is positioned for delicate areas including under the eyes. That is well over twice the concentration of Plinest Eye for the same anatomical area, which shows how far "eye" products differ between manufacturers. Do not carry volumes or technique from one brand's eye protocol to another's.
Croma renamed PhilArt to PolyPhil with the same formula, so older training material using the PhilArt name still applies. The range follows the familiar pattern of a general product plus Next, Eye and Hair variants. Ameela offers Rejuvenation and Eye products in 2.5 ml syringes. LUMI-PN is a more recent entrant with Face (20 mg/ml, 2.5 ml) and Eyes (20 mg/ml, 1.5 ml) options. Newer brands tend to compete on volume per syringe. They often have less published data behind them, which matters when a patient or an insurer asks what your product choice is based on.
Most ranges split along the same lines, so the practical question is which variant sits in which slot:
Manufacturer protocols generally call for a course of three or four sessions two to three weeks apart, followed by maintenance. Intervals and volumes are product-specific, so take them from the instructions for use, not from a competitor's protocol.
Patients often treat these as rival options, but they are different product classes. Profhilo and other hyaluronic acid skin boosters deliver HA. A polynucleotide gel delivers nucleotide chains and contains no HA unless it is a hybrid. Many clinics offer both, and hybrid gels exist because manufacturers treat the two ingredients as complementary.
Market data shows where polynucleotides now sit alongside them. An analysis of around 13,000 UK clinic websites by the consultancy Rare, reported by the Aesthetics Journal in September 2026, found 34% of clinics advertising skin boosters, 15% advertising polynucleotides and 14% advertising biostimulators. The share advertising polynucleotides had fallen by 5% year on year, although Rare noted it could not cleanly separate a real decline from clinics editing their public pages or from drift in its own measurement. Polynucleotides have settled in as an established add-on, and brand choice now matters more than simply having one on the menu.
It is growing, but it is uneven and brand-specific. A 2026 real-world study in Clinical, Cosmetic and Investigational Dermatology followed 61 subjects in five countries, 19 of them in the UK, treated for periorbital hyperpigmentation with PN-HPT at 7.5 mg/ml. They received three sessions two to three weeks apart. Pigmentation scores shifted significantly towards less severe grades, and 34.4% of subjects reported mild oedema or erythema, most of which settled the same day. The authors acknowledge the main weakness themselves: there was no control group.
Two points follow for product selection. First, data generated with one manufacturer's gel does not validate another's, because source, purification and chain length differ. Second, practitioners quoted in the Aesthetics Journal report called for independent, reproducible studies and advised against claims of tissue "regeneration" without evidence. Keep your own clinic marketing equally measured.
There is no single best brand, and published head-to-head comparisons between brands are scarce. Plinest is backed by the manufacturer's sizeable research programme. Others compete on concentration, syringe volume or rheology for a particular indication. Choose by indication, by the evidence available for that specific product, and by how the gel handles in your hands.
Among the widely used UK products, Nucleofill Strong is the most concentrated at 25 mg/ml (2.5%). Plinest, Vitaran I and LUMI-PN Face are all 20 mg/ml. Higher concentration does not mean more product per syringe: LUMI-PN Face delivers 50 mg in 2.5 ml against 37.5 mg in a 1.5 ml syringe of Nucleofill Strong.
Use a product made and labelled for the periocular area. These are often thinner or less concentrated to suit thin skin. Options include Plinest Eye at 7.5 mg/ml, Nucleofill Soft Plus, Rejuran I and Vitaran I. The published periorbital study cited above used a 7.5 mg/ml gel.
There are four broad types: polynucleotide-only gels for general skin quality, PN and hyaluronic acid hybrids for dehydrated skin, low-viscosity periocular products, and scalp formulations. Some ranges add a high-viscosity gel for scars.
Qualified practitioners can order from aesthetic trade suppliers. Filler World lists the brands covered here in its polynucleotides range.
Comparing polynucleotide brands comes down to a short list of checks: milligrams per syringe, viscosity suited to the area, whether you want HA in the gel, and how much published evidence sits behind that exact product. Stock a general facial product and a dedicated periocular one from a range you have trained on, verify the marking and lot details on every delivery, and describe outcomes to patients in terms the evidence supports.
